Internal Medicine Practice · Leipzig

dr. med. univ. albrecht wenzel

When sleep disrupts your metabolism.

The Night — Sleep Disorders & Apnea

What happens at night is decided by day.

In obstructive sleep apnea, the throat muscles relax during sleep and the airways narrow — often dozens of times per hour. Most people notice nothing but daytime fatigue. We clarify what happens at night: on an outpatient basis, in your own bed.

About 70 %

of people with severe obesity have obstructive sleep apnea — in most of them it had not been diagnosed before.Ravesloot et al., Eur Arch Otorhinolaryngol 2012 — polysomnography in 279 patients before bariatric surgery.

4 not 10

hours of sleep on two nights: 28 % more of the hunger hormone ghrelin, 18 % less of the satiety hormone leptin and markedly more appetite — especially for calorie-dense food.Spiegel et al., Ann Intern Med 2004 — 12 healthy young men, crossover design.

The Dawn — The Vicious Cycle

Sleep and weight — one cycle.

Sleep apnea fragments sleep and shifts the hunger hormones: more ghrelin, less leptin, more cortisol. The result is more appetite and an unfavourable fat distribution — including in the throat, which in turn worsens the apnea. This is exactly where treatment begins: at both ends.

10 %

less body weight was associated with about 26 % fewer nightly breathing pauses in a long-term study — in mild sleep apnea, weight loss can in suitable cases make CPAP therapy unnecessary.Peppard et al., JAMA 2000 (Wisconsin Sleep Cohort); Tuomilehto et al., Am J Respir Crit Care Med 2009.

S3 Guideline

The guideline on sleep-related breathing disorders explicitly recommends weight reduction for overweight patients.

Poor sleep and excess weight reinforce each other.
A cycle — one that can be broken at both ends.

The Day — Obesity Treatment

Weight is the strongest lever.

Weight reduction acts on the cause of sleep apnea — and improves blood pressure and metabolism at the same time. The foundation is always lifestyle: nutrition, movement and sleep. Medication can support that path — it cannot replace it. We treat according to the S3 obesity guideline: multimodal, destigmatising, and guided by what the findings actually show.

The Day — Medical Options

GLP-1 — when the injection supports.

GLP-1 receptor agonists and dual incretins (semaglutide, tirzepatide) amplify the effect of the body's own satiety hormones. In the SURMOUNT-OSA trial, tirzepatide markedly reduced the number of breathing pauses in obese sleep apnea patients — alongside weight loss (Malhotra et al., N Engl J Med 2024). The decision is always made by the person, not the medication.

The Practice

About the doctor.

dr. med. univ. Albrecht Wenzel — internist in Leipzig

dr. med. univ. Albrecht Wenzel

One practice, one focus: This site is the sleep-medicine offering of the internal medicine practice of dr. med. univ. Albrecht Wenzel — not a separate facility. Same practice, same team, same address at Georg-Schumann-Straße 257.

Board-certified specialist in internal medicine, focusing on the metabolic syndrome and its interconnections — in particular the interplay of sleep and weight.

Treatment is consistently based on the current S3 guidelines of the professional societies.

  • Obesity specialistDAG-DDG 2024
  • Nutritional medicineLÄK 2024
  • DiabetologyLÄK 2024
  • Sleep medicinein training

More about the doctor

This site shows the Sleep & Weight focus. The practice also offers diabetology and full primary care — to the practice's main website →

Contact

Contact & opening hours.

0341 5210871
info@internist-wenzel.de

Georg-Schumann-Straße 257 · 04159 Leipzig · Germany
Online appointments: Open Doctolib

Opening hours
Monday08:00 – 12:00 · 13:00 – 15:00
Tuesday08:00 – 12:00 · 13:00 – 18:00
Wednesday08:00 – 12:00 · 13:00 – 15:00
Thursday08:00 – 12:00 · 13:00 – 15:30 (extended consult., by appt.)
Friday08:00 – 12:00
Acute walk-in (no appointment)
Mon & Tue08:00 – 09:30
Wed – Fri08:00 – 09:00

Emergency: In medical emergencies, please call emergency services on 112. Outside consultation hours, the medical on-call service (116 117) can help.

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